The report synthesizes experiences from across Asia and the Pacific on how synergistic approaches can address the interconnected challenges of climate change, biodiversity loss and pollution, while accelerating progress towards the Sustainable Development Goals. Drawing on 36 featured case studies and more than 140 cases overall, it identifies four entry points for advancing synergies: health-centred climate action, nature-positive nexus approaches, circular economy approaches, and cities as delivery platforms. The report emphasizes that synergistic solutions require aligned finance, robust data and analytical tools, and effective governance arrangements. Regional cooperation can also help translate promising pilots into broader policy action.